In vivo evaluation of quorum-sensing inhibitor(QSI) and anti-biofilm forming formulations (single and multi-component) on printed femur implants
The project main objective to develop, characterize and offer in vivo proof-of-concept of the efficacy of novel 3D-printed implants, incorporating (or coated by) QSI (single and multi-components) and anti-biofilm forming formulations to protect against Staphylococcus spp. femur implant infections in mouse. In order to accomplish this task, the selected ESR will learn how to carry out an in depth characterization of in vitro activity on novel compounds against biofilm producing bacterial pathogens and to determine how this translates into in vivo efficacy in using the most relevant animal model of bacterial infections. He will be directly involved in the development and/or in the use of specific medium- to high-throughput in vitro assays and to perform in vivo efficacy studies, which will include also the including evaluation of PK/PD relationship required for translational purposes. Additionally, you will be expected to write project reports, to establish effective and proactive communication with the other members of the consortium and to contribute to the implementation of the training platform.
Profile and requirements
- You have a master degree, preferentially in microbiology, biochemistry, pharmaceutical sciences, or molecular biology
- You are willing to learn about the drug discovery process and associated in vitro tests for compound progression;
- You are willing to acquire scientific and technical skills for running relevant animal models of bacterial infections and you have no preclusion in manipulating laboratory animal species.
- You have a genuine interest in research and you are committed to make the difference in developing potential new drugs.
- You are highly motivated to work in a multidisciplinary team
- You have excellent organizational and communication skills and you are prepared to work under strict timelines
Host: APT Verona (Italy)
Duration*: 36 months