In vivo evaluation of antimicrobial peptide-based formulations (single and multi-component) on printed femur implants
Host: Academic Medical Center, Department of Medical Microbiology, Amsterdam, The Netherlands
The Academic Medical Center (AMC) in Amsterdam is one of the foremost research institutions in the Netherlands, as well as one of its largest hospitals. Over 7000 people work here to provide integrated patient care, fundamental and clinical scientific research, and teaching. The doctorate level academic training of AMC PhD students is organized in the AMC Graduate School. The School aims at creating an infrastructure that promotes and supports excellence in the doctorate level training of PhD students as highly qualified future professionals in an international environment. The ESR selected for the present vacancy will join the AMC Graduate School and have access to its extensive opportunities.
Moreover, the PRINT-AID project will provide training across a wide range of disciplines including biology, pharmacology, chemistry and material sciences, ensuring interdisciplinary and intersectoral experience. ESR7 can also take part in the EU COST Action TD1305 iPROMEDAI, Improved PROtection of Medical Devices Against Infection, with 26 European countries participating.
The present vacancy is part of the research line “Biomaterial-associated infections and novel antimicrobial strategies”, of Dr. S.A.J. Zaat, at the Department of Medical Microbiology of the AMC.
Early Stage Researcher (PhD candidate) for the PRINT-AID Innovative Training Network within the Marie Sklodowska Curie Programme (1.0 fte)
Application deadline: 15 March 2017
Early Stage Researcher 7: In vivo evaluation of antimicrobial peptide-based formulations (single and multi-component) on printed femur implants
The objectives of this project
To assess in vitro antimicrobial and anti-biofilm activity of novel implant surface coatings for additively manufactured (“3D-printed”) medical devices, based on highly potent SAAPs, Synthetic Antimicrobial and Antibiofilm Peptides. These SAAPs were developed in the recently completed EU FP7 project “BALI, the Biofilm Alliance” as high potential alternatives for conventional antibiotics.
To develop / optimize a murine Staphylococcus spp. femur implant infection model for quantitative assessment of infection control and wound healing / bone formation.
To study the efficacy of 3D-printed implants provided with the novel SAAP-containing antimicrobial coatings to prevent infection.
Planned secondment(s) during the project
ESR7 will be seconded to Voxdale (Belgium) to perform 3D-printing of the femur implants, and to Aptuit (Italy) for complementing in vivo experimentation.
What we are looking for
You have a strong motivation to conduct excellent research in antimicrobial strategies for implants, and a desire to contribute to patient well-being in preventing the dreaded complications of implant-associated infections. You are able to show that you can function as part of a multidisciplinary team and can perform laboratory experiments reliably. You are trained in (medical) microbiology and basic immunology, and are willing to conduct animal (mouse) experiments. Being certified to conduct animal experiments in the EU is highly recommended.
You will perform your PhD research in the multidisciplinary Innovative Training Network (ITN) project PRINT-AID.
To qualify, you must fulfill the following criteria
- Hold an MSc or equivalent in a relevant field.
- Be in the first four years of your research career, since e.g. completion of MSc. You cannot already possess a doctorate degree.
- Be willing to move to the Netherlands. Additionally, you must NOT have worked or studied for more than 12 months during the last 3 years in the Netherlands.
- Be proficient in both written and spoken English.
- Be eligible to be enrolled in the PhD programme at the host institution AMC.
What we have to offer
The MSCA programme offers highly competitive and attractive salary and working conditions. The successful candidates will receive a salary in accordance with the MSCA regulations for Early Stage Researchers. Exact salary will be confirmed upon appointment and consists of Living allowance (approximately €37.320 /year (depending on a correction factor to be applied per country) and Mobility allowance (approximately €7200 /year). Researcher’s may also qualify for a Family allowance of €6000 /year depending on the family situation. In addition to the individual scientific projects at host institution, all fellows will benefit from further continuing education, which includes intra-sectoral secondments within the PRINT-AID innovative training network, a variety of training modules as well as transferable skills courses and active participation in PRINT-AID workshops and summer schools.
Duration of the contract: 3 years.
Would you like to know more?
Are you interested?
Your application should include (and be limited to) the following attachments
- Letter of motivation
- Curriculum Vitae