European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality

Summary: The insertion of a foreign material usually elicits inflammation, what can result in hampered antimicrobial capacity of the host immunity due to the effort of immune cells being directed to degrading the material. For this reason, we developed a system based on the co-culture of HL-60 cells differentiated into polymorphonuclear leukocytes (PMNs) and Staphylococcus aureus (laboratory and clinical strains) on titanium as well as LDPE surfaces to assess the applicability of newly discovered biofilm inhibitors as part of implantable devices and endotracheal tubes.

Read the original article, published in Microorganisms here.