European training network for development of personalized anti-infective medical devices combining printing technologies and antimicrobial functionality

Few researchers have explored the possibility of directly 3D printing drug delivery systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. The produced samples were characterized in terms of their thermal, mechanical properties and bacterial and biofilm prevention.